Effect of Cisapride, Bethanechol and Erythromycin on immunoglobulin absorption of colostrum in neonatal calves

Prokinetics drug has a great ability to increase abomasal emptying rate and intestinal motility. The aim of this study was to evaluate the effect of the oral administration erythromycin, Cisapride and bethanechol as prokinetic agents on abomasal emptying rate and on Immunoglobulin absorption in neonatal calves. Twenty-Four Holstein neonate calves were divided in to four groups (3 treatments and a control) and each group including 6 newborn calves. Calves were fed 3‌ L of pooled cow colostrum containing acetaminophen (50 mg/kg, BW) by esophageal tube of control group. three treatment groups receive erythromycin (20 mg/kg, BW) and acetaminophen(50 mg/kg, BW); cisapide (0.5 mg/kg, BW) and acetaminophen (50 mg/kg, BW); bethanechol (0.5 mg/kg, BW) and acetaminophen (50 mg/kg, BW) has been added to 3 L of pooled cow colostrum. Abomasal emptying rate was assessed by plasma acetaminophen concentration. Pooled colostrum was obtained by harvesting of multiparous Holstein cows immediately after parturition. Venous blood samples for determination of plasma acetaminophen and serum Immunoglobulin concentration were obtained immediately before and after the start of colostrum administration.The results showed that administration of erythromycin and cisapride caused a significant increase in plasma acetaminophen and abomasal emptying rate (P