Effects of Oral Administration of Selenium Nanoparticles (SeNPs) and Sodium Selenite (NaSe) on Hematological Parameters and in SCNT Cloned and Non-cloned Pregnant Saanen Goats and their Offspring

The aim of the present study was to evaluate the effects of oral administration of selenium nanoparticle (SeNPs) and sodium selenite (NaSe) in cloned (using SCNT) and non-cloned Saanen pregnant goats in transition period on hematological parameters of goats and their SCNT and non-cloned offspring, including PCV, WBC, neutrophils and lymphocytes. 24 pregnant Saanen goats were randomly divided into 3 groups (n=8 in each group; 4 SCNT and 4 non-cloned) as follows: SeNPs, NaSe and control. Intervention (dosage: 0.05 mg/kg daily) commenced for 10 days, about 3 weeks before parturition. Blood samples were collected in goats: on days 14 and 7 before parturition, the day of parturition and on days 7 and 14 after parturition, and in kids: on the day of birth and 7 and 14 days after birth. The results revealed that SeNPs group had a higher increase in serum selenium level than NaSe and control groups. According to hematological parameters evaluations, on days 0 and +7, there was a significant increase in WBC, neutrophil and lymphocytes population, as well as a significant increase in PCV on day 0, in treatments compared with control, and in SeNPs compared with NaSe (P<0.05). Moreover, there was a significant correlation between changes in serum selenium levels and hematological parameters (P<0.05). In the current study, there were no significant difference between the cloned and non-cloned goats’ parameters. Therefore, it can be inferred that oral prescription of Nano selenium in transition period can positively influence hematological parameters including PCV, WBC, neutrophils and lymphocytes of both Sannen goats at the time of parturition and their offspring, more effectively than oral prescription of Sodium selenite. Also, it may be concluded that cloning does not alter the hematological parameters of Sannen goats around parturition and their offspring.