Evaluation of epidural administration of diclofenac sodium on hematobiochemical parameters, vital signs, electrical activity of heart and analgesia in sheep

Document Type : Original Article

Authors
Mehdi Abbasinia 1
Shahram Maleki 2
Amir Zakian 2
Abbas Raisi 2
1 DVM graduated student, Faculty of Veterinary Medicine, Lorestan University, Khorramabad- Iran.
2 Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad- Iran.
10.22034/ijvcs.2022.11199
Abstract
     This study was performed to evaluate analgesia and side effects of diclofenac sodium on vital signs, hematobiochemical parameters and electrocardiographic indices in Lori sheep after epidural anesthesia. Eighteen non-pregnant healthy sheep (3.00±2.46 years old) haphazardly separated into three groups and received the lidocaine (5 mg/kg), diclofenac sodium (5 mg/kg) or lidocaine (5 mg/kg) plus diclofenac sodium (5 mg/kg) via epidural injection into the first intercoccygeal space. Analgesia onset time and duration were recorded by needle testing on the tail, anus, perineum, vulva and inner thighs. Vital signs were recorded after epidural administration at 5, 15, 30, 45, 60, 90, and 120 minutes. Also, electrocardiography, blood oxygen saturation levels and venous blood samples were taken from all sheep at 30, 60 and 120 minutes. Onset and duration of analgesia in the diclofenac group was significantly longer and shorter than the other groups (p<0.05), respectively. The results of this study showed that diclofenac sodium with lidocaine increases the quality of epidural analgesia in sheep and has no negative effect on electrocardiogram (ECG) components and arterial oxygen saturation (SPO2). But it decreases packed cell volume concentration (PCV), red blood cells (RBC) and white blood cells (WBC) count. Therefore, due to these changes, using of diclofenac sodium for epidural anesthesia in sheep is not recommended with or without lidocaine.
Keywords
Epidural Anesthesia
Sheep
Hematology
Electrocardiography
Subjects
Iranian Journal of Veterinary Clinical Sciences
Volume 15, Issue 2 - Serial Number 26
Fall & winter 2021/2022
March 2022
Pages 17-28