The effect of vitamin D on apolipoprotein A1, cholesterol, and triglyceride in healthy adult male dog

Document Type : Original Article

Authors
Ebrahim Abhaji Ezzabadi
Nooshin Derakhshandeh 1
Mahboobeh Ashrafi 2
Saeed Nazifi 1
1 Department of Clinical Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz- Iran
2 Department of Basic Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz- Iran
10.22034/IJVCS.2024.14897.1102
Abstract
Vitamin D deficiency not only causes cardiovascular problems but also increases the risk factors for this disease. One of the reasons for reducing cardiovascular problems can be attributed to the improvement of dyslipidemia due to this vitamin. Many mechanisms have been reported for the effect of vitamin D on the lipid profile, but how vitamin D affects the lipid profile is still unknown. Considering that the impact of this supplement on the serum level of fat factors in dogs has not been investigated, therefore this study aimed to study the effect of vitamin D supplementation on serum levels of calcifediol (25-hydroxyvitamin D), cholesterol, triglycerides, and the composition of apolipoprotein A1 in healthy adult dogs. Eight adult male dogs of mixed breed were selected and kept. Then an oral vitamin D supplement of 50 IU/kg was prescribed for 42 days. Serum levels of calcifediol and cholesterol, triglycerides, and the level of apolipoprotein A1 composition before treatment (day 0) and days 14, 28, and 42 as days after treatment were investigated. Based on the results obtained, after administering this supplement, the serum level of calcifediol showed an increasing trend (P=0.04). Vitamin D did not affect the level of VLDL composition in the blood, but it led to an increase in the level of triglyceride (P=0.0005), and cholesterol (P<0.05). However, the level of serum apolipoprotein A1 was reduced during the study. Considering the dosage of this supplement and the duration of administration, it is necessary to conduct additional research in this field.
Keywords
Apolipoprotein A1
Calcifediol
Cholesterol
Triglyceride
Dog
Subjects
1. Abdulrahman, MA; Alkass, SY. and Mohammed, NI; Total and free vitamin D status among apparently healthy adults living in Duhok Governorate. Scientific Reports; 2022; 12(1), 1778.
2.Alizadeh, K; Ahmadi, S; Sarchahi, AA. and Mohri, M; The effects of age, sex, breed, diet, reproductive status and housing condition on the amounts of 25 (OH) vitamin D in the serum of healthy dogs: Reference values. Veterinary Medicine and Science; 2022; 8(6), 2360-2366.
3.Chehsmazar, E; Zarrati, M; Yazdani, B; Razmpoosh, E; Hosseini, AF. and Shidfar, F; The effect of vitamin D supplementation on serum concentrations of dehydroepiandrosterone, paraoxonase 1, apolipoproteins, free fatty acid and insulin in vitamin D deficient obese and overweight individuals under a low-calorie diet program: a randomized controlled trial. Nutrition and Food Science; 2020; 51(5), 765-780.
4.Forouhi, NG; Menon, RK; Sharp, SJ; Mannan, N; Timms, PM; Martineau, AR. and Hitman, GA; Effects of vitamin D2 or D3 supplementation on glycaemic control and cardiometabolic risk among people at risk of type 2 diabetes: results of a randomized double‐blind placebo‐controlled trial. Diabetes, Obesity and Metabolism, 2016; 18(4), 392-400.
5.George, PS; Pearson, ER. and Witham, MD; Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta‐analysis. Diabetic Medicine, 2012; 29(8), e142-e150.
6.Hariri, Z; Kord-Varkaneh, H; Alyahya, N; Prabahar, K; Găman, MA. and Abu-Zaid, A; Higher dietary vitamin D intake influences the lipid profile and hs-CRP concentrations: Cross-sectional assessment based on the national health and nutrition examination survey. Life, 2023; 13(2), 581.
7.Hu, Z; Zhi, X; Li, J; Li, B; Wang, J; Zhu, J. and Zhang, Z; Effects of long-term vitamin D supplementation on metabolic profile in middle-aged and elderly patients with type 2 diabetes. The Journal of Steroid Biochemistry and Molecular Biology; 2023; 225, 106198.
8.Jorde, R. and Grimnes, G; Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids. Progress in Lipid Research, 2011; 50(4), 303-312.
9.Sabico, S; Wani, K; Grant, WB. and Al-Daghri, NM; Improved HDL cholesterol through vitamin D status correction substantially lowers 10-Year atherosclerotic cardiovascular disease risk score in vitamin D-deficient Arab adults. Nutrients; 2023; 15(3), 551.
10.Salehpour, A; Shidfar, F; Hosseinpanah, F; Vafa, M; Razaghi, M; Hoshiarrad, A. and Gohari, M; Vitamin D3 and the risk of CVD in overweight and obese women: a randomised controlled trial. British Journal of Nutrition; 2012; 108(10), 1866-1873.
11.Serrano, NC; Rojas, LZ; Gamboa-Delgado, EM; Suárez, DP; Acosta, IS; Romero, SL. and Quintero-Lesmes, DC; Efficacy of vitamin D supplementation in reducing body mass index and lipid profile in healthy young adults in Colombia: a pilot randomised controlled clinical trial. Journal of Nutritional Science; 2023; 12, e29.
12.Stounbjerg, NG; Mølgaard, C; Cashman, KD; Michaelsen, KF. and Damsgaard, CT; Vitamin D status of 3-year-old children in Denmark: determinants and associations with bone mineralisation and blood lipids. European Journal of Nutrition; 2023; 62(3), 1441-1451.
13.Wang, Y; Si, S; Liu, J; Wang, Z; Jia, H; Feng, K. and Song, SJ; The associations of serum lipids with vitamin D status. PloS One; 2016; 11(10), e0165157.
14.Weidner, N. and Verbrugghe, A; Current knowledge of vitamin D in dogs. Critical Reviews in Food Science and Nutrition; 2017; 57(18), 3850-3859.
15.Wood, AD; Secombes, KR; Thies, F; Aucott, L; Black, AJ; Mavroeidi, A. and Macdonald, HM; Vitamin D3 supplementation has no effect on conventional cardiovascular risk factors: a parallel-group, double-blind, placebo-controlled RCT. The Journal of Clinical Endocrinology and Metabolism; 2012; 97(10), 3557-3568.
16.Yarparvar, A; Elmadfa, I; Djazayery, A; Abdollahi, Z; Salehi, F. and Heshmat, R; The effects of vitamin D supplementation on lipid and inflammatory profile of healthy adolescent boys: a randomized controlled trial. Nutrients; 2020; 12(5), 1213.
Iranian Journal of Veterinary Clinical Sciences
Volume 18, Issue 2 - Serial Number 31
Fall & winter 2024/2025
January 2025
Pages 89-97