The effect of vitamin D on apolipoprotein A1, cholesterol, and triglyceride in healthy adult male dog

Vitamin D deficiency not only causes cardiovascular problems but also increases the risk factors for this disease. One of the reasons for reducing cardiovascular problems can be attributed to the improvement of dyslipidemia due to this vitamin. Many mechanisms have been reported for the effect of vitamin D on the lipid profile, but how vitamin D affects the lipid profile is still unknown. Considering that the impact of this supplement on the serum level of fat factors in dogs has not been investigated, therefore this study aimed to study the effect of vitamin D supplementation on serum levels of calcifediol (25-hydroxyvitamin D), cholesterol, triglycerides, and the composition of apolipoprotein A1 in healthy adult dogs. Eight adult male dogs of mixed breed were selected and kept. Then an oral vitamin D supplement of 50 IU/kg was prescribed for 42 days. Serum levels of calcifediol and cholesterol, triglycerides, and the level of apolipoprotein A1 composition before treatment (day 0) and days 14, 28, and 42 as days after treatment were investigated. Based on the results obtained, after administering this supplement, the serum level of calcifediol showed an increasing trend (P=0.04). Vitamin D did not affect the level of VLDL composition in the blood, but it led to an increase in the level of triglyceride (P=0.0005), and cholesterol (P<0.05). However, the level of serum apolipoprotein A1 was reduced during the study. Considering the dosage of this supplement and the duration of administration, it is necessary to conduct additional research in this field.