بررسی اثرات بالینی تزریق داخل رحمی پماد پستانی حاوی سفاپیرین بنزاتین در درمان اندومتریت گاوهای شیری نژاد هلشتاین

نوع مقاله : مقاله پژوهشی

نویسندگان
سروش وحیدمقتدا 1
نوید اعرابی 2
عباس روشن قصرالدشتی 2
1 دانشکده دامپزشکی، دانشگاه آزاد اسلامی واحد کازرون، کازرون، ایران
2 گروه علوم درمانگاهی دانشکده دامپزشکی، دانشگاه آزاد اسلامی واحد کازرون،کازرون، ایران
10.22034/ijvcs.2023.14046.1032
چکیده
اندومتریت در گاو به عنوان التهاب لایه داخلی رحم تعریف و به اندومتریت بالینی و تحت بالینی تقسیم می‌شود. به دلیل اثر اقتصادی تاخیر در درمان و کاهش عملکرد باروری، توجیه برای شناسایی این بیماری در سریع‌ترین زمان ممکن وجود دارد. هدف از مطالعه حاضر بررسی اثرات بالینی تزریق داخل رحمی پماد پستانی حاوی سفاپیرین در درمان اندومتریت گاوهای شیری نژاد هلشتاین و مقایسه عملکرد آن با دو درمان رایج اندومتریت؛ یعنی پروستاگلاندین و اکسی‌تتراسایکلین (انفوزیون داخل‌رحمی) است. مطالعه حاضر در یک واحد از گاوداری‌‌‌های صنعتی و با استفاده از 150 راس گاو هلشتاین مبتلا به اندومتریت که به صورت تصادفی در سه گروه 50 راسی دریافت کننده کلوپروستنول، تتراسایکلین و پماد داخل پستانی سفاپیرین‌بنزاتین تقسیم شده بودند، انجام گرفت. در مطالعه حاضر مشخص شد داروی سفاپیرین به صورت معنی‌داری نسبت به کلوپرستنول باعث کاهش ترشحات رحمی (008/0 = P)، افزایش نرخ آبستنی (001/0 = P) و کاهش فاصله درمان تا آبستنی (008/0 = P) می‌شود. علاوه بر این سفاپیرین توانست به صورت معنی‌داری نسبت به اکسی‌تتراسایکلین باعث کاهش فاصله درمان تا آبستنی (008/0 = P) شود. درباره شاخص وضعیت بدنی و میزان تولید شیر در بین گروه‌های مختلف تفاوت معنی‌داری مشاهده نشد. بنابر پژوهش حاضر، ترتیب داروها در تاثیر درمانی بر اندومتریت عبارت است از: سفاپیرین، اکسی‌تتراسایکلین و کلوپرستنول. با توجه به محدود کاربرد انسانی دارو، نفوذ کم در شیر و طیف اثر مناسب علیه گرم مثبت و منفی‌ها، به نظر می‌رسد سفاپیرین داروی مناسبی برای درمان اندومتریت گاوهای شیری باشد.
کلیدواژه‌ها
سفالوسپورین ها
هلشتاین
سفاپیرین
اندومتریت
موضوعات

عنوان مقاله English

Investigating the clinical effects of intrauterine injection of intramammary infusion containing Cephapirin-benzathine in the treatment of endometritis in Holstein dairy cows

نویسندگان English

Soroush Vahidmoghtada 1
Navid Aarabi 2
Abbas Rowshan-Ghasrodashti 2
1 Faculty of Veterinary Medicine, Islamic Azad University, Kazerun branch, Kazerun, Iran
2 Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Kazerun Branch, Kazerun, Iran
چکیده English

Endometritis in cows is defined as the inflammation of the inner lining of the uterus and is divided into clinical and cytological. Because of the economic impact of delay in the treatment and reduced reproductive performance, there is a justification for identifying this disease as soon as possible. The aim of this study is to investigate the clinical effects of an intrauterine injection of intramammary ointment containing Cefapirin-benzathine in the treatment of endometritis in Holstein dairy cows and to compare its efficacy with two common treatments of endometritis, i.e. Prostaglandin and oxytetracycline. The present study was conducted in a unit of industrial cattle farm and among 150 cows with endometritis who were randomly divided into three groups of 50 cows receiving cloprostenol, oxytetracycline, and Cefapirin benzathine. It was found that Cefapirin significantly reduced uterine secretions, increased the pregnancy rate, and reduces the treatment to pregnancy interval compared to cloprostenol. In addition, cefapirin was able to significantly reduce the treatment to pregnancy interval compared to oxytetracycline. No significant difference was observed in the body condition score and the amount of milk production among different groups. According to the present research, the order of drug’s therapeutic effect on endometritis is cefapirin, oxytetracycline, and cloprostenol. Due to its limited human use, low diffusion to milk, and appropriate spectrum of effect against gram-positive and negative bacteria, Cefapirin seems to be a suitable drug for the treatment of endometritis in dairy cows

کلیدواژه‌ها English

Cephalosporins
Holstein
cefapirin
endometritis
1.Adnane M, Kaidi R, Hanzen C, England GCW. Risk factors of clinical and subclinical endometritis in cattle: a review. Turkish Journal of Veterinary & Animal Sciences. 2017;41(1):1–11.
2. Ahmadi M, Nazifi S, Gheisari H. The effect of intrauterine cefapirin in the treatment of endometritis in commercial dairy cows. Archives of Razi Institute. 2016;59(2).
3. Ahmadi MR, Hosseini A, Gheisari HR, Yavari M. Preliminary trial in treatment of postpartum endometritis with intrauterine application of hyperimmune serum in dairy cows. Asian Pacific Journal of Tropical Disease. 2014;4:S360–S365.
4. Armengol R, Fraile L. Comparison of two treatment strategies for cows with metritis in high-risk lactating dairy cows. Theriogenology. 2015;83(8):1344–1351.
5. Barlund CS, Carruthers TD, Waldner CL, Palmer CW. A comparison of diagnostic techniques for postpartum endometritis in dairy cattle. Theriogenology. 2008; 69(6): 714–723.
6. Cohen RO, Bernstein M, Ziv G. Isolation and antimicrobial susceptibility of Actinomyces pyogenes recovered from the uterus of dairy cows with retained fetal membranes and post parturient endometritis. Theriogenology. 1995; 43(8): 1389–1397.
7. Denis-Robichaud J, Dubuc J. Randomized clinical trial of intrauterine cephapirin infusion in dairy cows for the treatment of purulent vaginal discharge and cytological endometritis. Journal of Dairy Science. 2015; 98(10): 6856–6864.
8. Ghasemzadeh H, Malekan m, Bokaee S. Comparison of three different protocols to treat endometritis in dairy cows. Iranian Journal of Veterinary Clinical Sciences. 2008;2(1):12–21.
9. Grousi M, Rashti M. Study of the clinical effects of Cephapirin Benzathine on endometritis treatment of Holstein dairy cows. Iranian Journal of Veterinary Clinical Sciences. 2008;2(1):1–7.
10. Hajibemani A. The effect of intrauterine administration of Zataria multiflora ex-tract in cows with clinical endometritis on the incidence of abortion in subsequent pregnancy. New Findings in Veterinary Microbiology. 2020;2(2):105–115.
11. Hussain AM, Daniel RCW. Bovine endometritis: current and future alternative therapy. Journal of Veterinary Medicine Series A. 1991;38(1‐10):641–651.
12. Jasso-Miranda C, Herrera-Camacho I, Flores-Mendoza LK, Dominguez F, Vallejo-Ruiz V, Sanchez-Burgos GG, Pando-Robles V, Santos-Lopez G, Reyes-Leyva J. Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies. Infection and drug resistance. 2019; 12: 1833.
13. Keshavarz S, FallafRad AH, Heidarpour M. Comparison of three treatment protocols of clinical endometritis in dairy cows 21-33 days post-partum. Veterinary Researches & Biological Products. 2016;29(2):8–14.
14. Lester R, Musicha P, Van Ginneken N, Dramowski A, Hamer DH, Garner P, Feasey NA. Prevalence and outcome of bloodstream infections due to third-generation cephalosporin-resistant Enterobacteriaceae in sub-Saharan Africa: a systematic review. Journal of Antimicrobial Chemotherapy. 2020;75(3):492–507.
15. Nath AP, Balasubramanian A, Ramalingam K. Cephalosporins: An imperative antibiotic over the generations. International Journal of Research in Pharmaceutical Sciences. 2020;11(1):623–630.
16. Okawa H, Wijayagunawardane MMP, Vos PLAM, Yamato O, Taniguchi M, Takagi M. Effects of intrauterine infusion of a chitosan solution on recovery and subsequent reproductive performance of early postpartum dairy cows with endometritis: a pilot field trial. Animals. 2021;11(1):197.
17. Parikh SS, Kavani FS, Parmar KH, Patbandha TK, Singh VK, Ahlawat AR, Kumar R. Diagnostic and therapeutic management of subclinical endometritis in dairy bovine: A Review. Animal Reproduction Update. 2022; 2(2): 1–11.
18. Pascottini OB, Hostens M, Sys P, Vercauteren P, Opsomer G. Cytological endometritis at artificial insemination in dairy cows: Prevalence and effect on pregnancy outcome. Journal of dairy science. 2017;100(1):588–597.
19. Schaefer D. Yield and quality of Holstein beef. University of Minnesota Dairy publisher; 2005.
20. Sheldon IM, Lewis GS, LeBlanc S, Gilbert RO. Defining postpartum uterine disease in cattle. Theriogenology. 2006; 65(8): 1516–1530.
21. Sheldon IM, Price SB, Cronin J, Gilbert RO, Gadsby JE. Mechanisms of infertility associated with clinical and subclinical endometritis in high producing dairy cattle. Reproduction in domestic animals. 2009;44:1–9.
22. Thongrueang N, Liu S-S, Hsu H-Y, Lee H-H. An in vitro comparison of antimicrobial efficacy and cytotoxicity between povidone-iodine and chlorhexidine for treating clinical endometritis in dairy cows. Plos one. 2022;17(7):e0271274.
23. Thurmond MC, Jameson CM, Picanso JP. Effect of intrauterine antimicrobial treatment in reducing calving-to-conception interval in cows with endometritis. Journal of the American Veterinary Medical Association. 1993;203(11):1576–1578.
24. Tison N, Bouchard E, DesCôteaux L, Lefebvre RC. Effectiveness of intrauterine treatment with cephapirin in dairy cows with purulent vaginal discharge. Theriogenology. 2017;89:305–317.
25. Tsakalof P, Fouskos A, Boskos K, Saratsis F, Samouilidou G. Treatment of chronic endometritis in the cow with PGF2a. Deltio tis Ellinikis Ktiniatrikis Etaireias (Greece). 1987.
26. Wagener K, Gabler C, Drillich M. A review of the ongoing discussion about definition, diagnosis and pathomechanism of subclinical endometritis in dairy cows. Theriogenology. 2017;94:21–30.
27. Yáñez U, Herradón PG, Becerra JJ, Peña AI, Quintela LA. Relationship between Postpartum Metabolic Status and Subclinical Endometritis in Dairy Cattle. Animals. 2022;12(3):242.
28. Yildirim EA, Brazhnik EA, Ilina LA, Laptev GY, Filippova VA, Kalitkina KA. Composition and functions of rumen and endometrial microorganisms associated with endometritis in dairy cows. In: BIO Web of Conferences. Vol. 48. EDP Sciences; 2022. p. 3008.
علوم درمانگاهی دامپزشکی ایران
دوره 17، شماره 1 - شماره پیاپی 28
بهار و تابستان 1402
شهریور 1402
صفحه 3-11