بررسی اثرات بالینی تزریق داخل رحمی پماد پستانی حاوی سفاپیرین بنزاتین در درمان اندومتریت گاوهای شیری نژاد هلشتاین

Endometritis in cows is defined as the inflammation of the inner lining of the uterus and is divided into clinical and cytological. Because of the economic impact of delay in the treatment and reduced reproductive performance, there is a justification for identifying this disease as soon as possible. The aim of this study is to investigate the clinical effects of an intrauterine injection of intramammary ointment containing Cefapirin-benzathine in the treatment of endometritis in Holstein dairy cows and to compare its efficacy with two common treatments of endometritis, i.e. Prostaglandin and oxytetracycline. The present study was conducted in a unit of industrial cattle farm and among 150 cows with endometritis who were randomly divided into three groups of 50 cows receiving cloprostenol, oxytetracycline, and Cefapirin benzathine. It was found that Cefapirin significantly reduced uterine secretions, increased the pregnancy rate, and reduces the treatment to pregnancy interval compared to cloprostenol. In addition, cefapirin was able to significantly reduce the treatment to pregnancy interval compared to oxytetracycline. No significant difference was observed in the body condition score and the amount of milk production among different groups. According to the present research, the order of drug’s therapeutic effect on endometritis is cefapirin, oxytetracycline, and cloprostenol. Due to its limited human use, low diffusion to milk, and appropriate spectrum of effect against gram-positive and negative bacteria, Cefapirin seems to be a suitable drug for the treatment of endometritis in dairy cows