غلظت سرمی لپتین و انسولین و ارتباط آن با پروفایل لیپیدی در گاو‌های هلشتاین قبل و بعد از زایمان

نوع مقاله : مقاله پژوهشی

نویسندگان
پدرام پرورده 1
سیده ام البنین قاسمیان 2
لیلا درخشان 1
1 گروه دامپزشکی، واحد شوشتر، دانشگاه آزاد اسلامی، شوشتر- ایران
2 گروه دامپزشکی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان-
/10.22034/ijvcs.2025.14912.1105
چکیده
از زمان شروع تا میانه آبستنی در دام‌ها، لپتین موجود در خون افزایش می‌یابد و تا انتهای آبستنی بالا باقی می‌ماند. با اینحال، مطالعات بیشتری برای بررسی نقش لپتین در فیزیولوژی ساخت و متابولیسم چربی جهت شناخت مکانیسم‌های موثر آن، باید صورت گیرد. مطالعه حاضر با هدف بررسی غلظت سرمی لپتین و انسولین و ارتباط آن با پروفایل لیپیدی در گاو هلشتاین قبل و بعد از زایمان صورت گرفت. مطالعه حاضر یک تحقیق آزمایشی بنیادی بود که روی 50 رأس گاو هلشتاین آبستن که طی فروردین 1402 تا دی ماه 1402 در گاوداری صنعتی شهرستان باغملک نگهداری می‌شدند، صورت گرفت. نمونه‌های سرم از 50 گاو هلشتاین دو هفته قبل و بعد از زایمان،  جمع‌آوری شد و مقادیر لپتین، انسولین، تری‌گلیسرید، کلسترول، HDL و LDL توسط کیت‌های الایزا و تشخیص طبی اندازه‌گیری شد. یافته‌ها حاکی از کاهش میزان لپتین و انسولین در گاوها پس از زایمان و افزایش میزان تری‌گلسیرید، کلسترول و LDL پس از زایمان نسبت به قبل آن بود (05/0>P). تجزیه داده‌ها همبستگی مثبت بالایی بین غلظت لپتین و انسولین خون نشان داد. همچنین، تغییر غلظت لپتین تحت تأثیر تری‌گلیسیرید (80/0=r)، کلسترول (67/0=r) و LDL (68/0=r) بود. غلظت انسولین نیز  با میزان تری‌گلیسیرید (52/0=r)، کلسترول (67/0=r) و LDL (63/0=r) همبستگی معنی‌دار داشت. به نظر می‌رسد که کاهش مقادیر لپتین و انسولین با افزایش مقادیر تری‌گلیسیرید،  کلسترول و LDL در ارتباط است.
کلیدواژه‌ها
گاو هلشتاین
لپتین
انسولین
تری‌گلیسرید
کلسترول
HDL
LDL

عنوان مقاله English

Serum Leptin and Insulin Concentration and its Relationship with Lipid Profile in Holstein Cows during the Prepartum and Postpartum

نویسندگان English

Pedram Parvardeh 1
Seyedeh Ommolbanin Ghasemian 2
Leila Derakhshan 1
1 Department of Veterinary, Shoushtar Branch, Islamic Azad University, Shoushtar- Iran.
2 Department of Veterinary, Behbahan Branch, Islamic Azad University, Behbahan- Iran.
چکیده English

From early to mid-pregnancy in cattle, blood leptin levels increase and remain elevated until the end of pregnancy. However, further studies are needed to understand leptin’s role in fat production and metabolism. This study aimed to investigate the serum concentrations of leptin and insulin and their relationship with the lipid profile in Holstein cows before and after parturition. This basic experimental research was conducted on 50 pregnant Holstein cows kept in industrial cattle farm in Bagmalek from April 1402 to January 1402. Serum samples were collected from these cows two weeks before and after calving. The levels of leptin, insulin, triglycerides, cholesterol, HDL, and LDL were measured using ELISA kits and medical diagnostics. The findings indicated a decrease in leptin and insulin levels in cows after calving, along with an increase in triglyceride, cholesterol, and LDL levels compared to pre-calving levels (P˂0.05). Data analysis showed a strong positive correlation between blood leptin and insulin concentrations. Additionally, changes in leptin concentration were influenced by triglyceride (r=0.80), cholesterol (r=0.67), and LDL (r=0.63). Insulin concentration was also significantly correlated with triglyceride (r=0.52), cholesterol (r=0.67), and LDL (r=0.63). The reduction in leptin and insulin levels appears to be related to the increase in triglyceride, cholesterol, and LDL levels.

کلیدواژه‌ها English

Holstein cow
leptin
insulin
triglyceride
cholesterol
HDL
LDL
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علوم درمانگاهی دامپزشکی ایران
دوره 19، شماره 1 - شماره پیاپی 32
بهار و تابستان 1404
مرداد 1404
صفحه 75-83