The Effect of hydroalcoholic extract of asafetida resin on serum levels of sexual hormones in female Wistar rats with Polycystic Ovarian Syndrome (PCOS)

Authors
majid morovatisharifabad
elham salehi
mohamad rostami
Abstract
Polycystic Ovary Syndrome (PCOS), is a complex endocrine and metabolic disorder, which is characterized by ovulatory dysfunction and hyperandrogenism. According to antioxidant properties effects of asafoetida, this study was done to evaluate the effect of hydroalcoholic extract of asafetida resin on the status of sex hormones in PCOS rat model. In the present experimental study, ?? adult female rats were divided into ? groups, negative control,who did not receive any treatment, positive control(PCOS) who received only estradiol valerate and three experimental groups, which first PCOS was induced in them ,then were treated with ??, ?? and ?? mg/kg BW of extract of asafetida resin. PCOS was induced by estradiol Valerate injection at the estrous cycle. The data suggests that extract of resin asafotida increased serum concentration of FSH and decreased LH and Testosterone in treatment groups. There were significant differences reported on FSH at ?? mg/kg, LH at ?? and ?? mg/kg, and Testosterone at ??, ?? and ?? doses in comparison with PCOS groups (p
Keywords
Polycystic Ovary Syndrome
Rat
Resin of Asafetida
Testosterone
Luteinizing Hormone
Follicle Stimulating Hormone