بررسی اثرات التیامى اسانس مریم‌گلی (Salvia officinalis) در زخم تجربی پوست در کبوتر (Columba livia domestica)؛ مطالعه هیستوپاتولوژی

Wound healing has been important for a long time, and using medicinal plants to speed up this procedure has always appealed to mankind. Salvia officinalis possesses antibacterial, antioxidant, and anti-inflammatory properties. This study was conducted to investigate the therapeutic effects of ointment containing Salvia officinalis essential oil (SOO) on the excisional full-thickness experimental wounds of pigeons. For this purpose, 18 healthy pigeons were utilized and two full-thickness 5-millimeter diameter cutaneous wounds were induced on the dorsal area of their neck. Then they were classified into 3 groups, control (Eucerin ointment), SOO2% (Eucerin ointment containing EOO 2%), and SOO 4% (Eucerin ointment containing SOO4%). Every day the wound surface of all groups was covered by the ointment for 14 days. On days 3, 7, and 14 after wound induction, macroscopical analysis of the wound surface was performed and then biopsy specimens were dissected and further investigations were conducted. Macroscopical observation revealed the faster healing process of the wounds in the groups treated by SOO, especially SOO4% on all days. Moreover, microscopical examinations supported the macroscopic results indicating less inflammation, better neovascularization, notable re-epithelialization, and more mature granulation tissue production and collagen deposition in the area of wound healing in SOO-treated animals, specially, SOO 4% on all experiment days. We can conclude that the administration of Salvia officinalis essential oil can be effective in wound healing and can accelerate healing process.